The spiFEG locus in Streptococcus infantarius subsp. infantarius BAA-102 confers protection against nisin U.

نویسندگان

  • Lorraine A Draper
  • John R Tagg
  • Colin Hill
  • Paul D Cotter
  • R Paul Ross
چکیده

Nisin U is a member of the extended nisin family of lantibiotics. Here we identify the presence of nisin U immunity gene homologues in Streptococcus infantarius subsp. infantarius BAA-102. Heterologous expression of these genes in Lactococcus lactis subsp. cremoris HP confers protection to nisin U and other members of the nisin family, thereby establishing that the recently identified phenomenon of resistance through immune mimicry also occurs with respect to nisin.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 56 1  شماره 

صفحات  -

تاریخ انتشار 2012